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|Title:||COMPARATIVE STUDY ON THE PROTECTIVE EFFECTS OF VITAMINE C, G, LATIFOLIUM AND P. GUINEENSE ON MOSQUITO COIL SMOKE - INDUCED LIVER AND HEART TOXICITY|
|Authors:||UGWU OKECHUKWU OGBONNIA|
|Abstract:||.ABSTACT The comparative study on the protective effects of vitamin C, G . latifolium and P. quineense on mosquito coil smokes-induced liver and heart toxicity were investigated. A total of 51 albino rats were grouped into five: A, B, C, D and E. While group A animals were used as control, groups B, C, D and E were exposed to different brands of mosquito coil (Rambo Raid, Baygon and Cork) smoke, respectively. Each group contained 12 rats, subdivided into four (1, 2, 3 and 4) with three (3) rats in each sub-group. Sub -groups 1, 2 and 3 were administered with vitamin C, G. latifolium and P. guineense extract,' respectively, while sub-group 4 rats served as negative control .The phytochemical and proximate analyses of G. latifolium and P. quineense extracts showed the presence of alkaloids, flavonoids, saponins, tannins, vitamin C, protein, carbohydrate, crude fibre and moisture contents. The result showed that for rats exposed to the smokes of different brands of mosquito coil only, serum levels of AST, ALP, ALT, creatinine and total bilirubin increased significantly (p= 0.05) while albumin, total protein, Haemoglobin and PCV decreased significantly (p< 0.05),compared to the control .This shows the toxic effects of the mosquito coil smokes. Comparing the relative toxicity of the various mosquito coil smoke, the result showed that cork mosquito coil exerted the highest level of toxicity followed by raid mosquito' coil. However, for rats exposed to mosquito coil smokes and simultaneously given vitamin C, G. latifolium and P. quineense .the levels of the above parameters were significant different (P<0.05) from the control, showing the protective effects of extracts and vitamin C against the toxicity of mosquito coil smoke exposure. The highest protective effect was observed in the animals co-treated with vitamin C followed by G.latifolium and P. guineense. Histological analysis of the extracts showed the damaging effects of the mosquito coil smoke on the liver such as distortion of hepatic architecture, haemorrhage and focal areas of necrosis, while fragmentation and clumping of cardiac muscle fibres,myocardial haemorrhages and inflammation were the damaging effects observed on the heart of the exposed rats. It was observed from the result that the consumption of G.latifolium, P. guinesse extracts and vitamin C can reduce the damaging effects of smoke from mosquito coil.|
|Description:||A DISSERTATION PRESENTED TO THE DEPARTMENT OF APPLIED BIOLOGY, EBONYI STATE UNIVERSITY, ABAKALIKI. IN PARTIAL FULFILLMENT OF THE REQUIREMENT FOR THE AWARD OF THE DEGREE OF MASTERS IN SCIENCE IN BIOCHEMISTRY|
|Appears in Collections:||Thesis & Dissertation|
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